> Familial Natural Short Sleep (FNSS), a benign mutation that allows them to sleep 1-2 hours less than the recommended 7-9 hours, without experiencing the negative effects of sleep deprivation.
Sleep deprivation is one concern, but there’s a more subtle impact on cognitive functions (working memory, creativity, deep focus), overall health (particularly the endocrine and immune systems), and long-term health outcomes (such as an increased risk of dementia).
When I was younger, I was fascinated by various optimized sleep schedules. However, I noticed a stark contrast: many of my math friends consistently slept 9–10 hours a day. They needed that—not just to function in daily life but to achieve the deep focus required for their work. Living on less sleep might not affect immediate action (and in some cases, it might even seem to enhance focus on doing), but it can impair deeper, more complex thinking.
Some suggest that one of sleep's key roles is to help the brain regenerate. Chronic sleep deprivation, in turn, is linked to a higher risk of dementia. For anecdotal evidence: Churchill and Thatcher, known for boasting about sleeping only 4–5 hours a night, experienced significant cognitive decline later in life.
Hey, discussion of orexin receptor stuff! As someone with clinically-diagnosed insomnia, I've been lucky enough to/unfortunate enough to have to try the orexin receptor antagonist sleep aids for a while. As recent, on-patent drugs, they are very, very expensive ($360/month was the number marked on the receipt slip, not that that means much in the US; I certainly wasn't paying that)... and they work. They really, really do work. I was prescribed them because I tried every single other class of sleep aid on the market and they were mostly ineffective, had massive side effects, or were benzos (temazepam: best sleep of my life, but better not use it for longer than a month!).
This stuff? Orexin receptor antagonists? They work. Holy crap, do they ever work. Sleep quality better than the Z-drugs, great tolerability, no massive disruption going off them... when these things go off-patent they're going to be massive. Sleep quality was not perfect (maybe 80% of "normal"? I don't know) but that is absolutely minor compared to the alternative.
(And for the record, I'm off them now due to other stuff clearing up such that I don't need this level of sleep assistance anymore. Not because I can't afford them.)
I guess that's a long-winded way to say that if you're going to do questionably-advised sleep biohacking, orexin receptors are probably the place to start.
It's notable that almost every animal sleeps in some way, even organisms that are away from sunlight (ie. creatures that live underground).
If you sleep 30% of the time, that's 30% of the time you aren't eating, mating, etc. Also, during sleep you are more vulnerable to predators. One would expect evolution to get rid of sleep in creatures who don't rely on sunlight cycles.
So, there must be some really good evolutionary reason for sleep.
I work in the sleep space, particularly enhancing slow-wave sleep - the synchronous firing of neurons which define deep sleep, the most restorative and vital component of sleep.
Only focusing on the amount of time asleep is a significantly limited viewpoint, but I believe this will change in the coming years as we gather more knowledge of sleep and access to EEG data about our brain activity during sleep increases.
Only measuring sleep time is like measuring the health of a persons diet is by measuring how much time they spent eating, but of course, looking at macronutrients, calories, is the right way of doing it.
I'll be writing more about this in the coming months, but my current thinking is that the concept of "can we sleep less" isn't the correct approach, and can be dangerous. At AffectableSleep.com - we increase the efficiency of deep sleep, and much of the research (https://affectablesleep.com/research) focuses on enhancing deep sleep in sleep deprived individuals (I'll post more research soon). This doesn't mean we should be sleeping less. A lack of quality sleep is already an epidemic in society, and massively underreported because the focus of the sleep industry has been the amount of time asleep, not the restorative functions of sleep.
Our goal isn't to help you sleep less, and we will need to be very clear in our marketing, but rather to ensure the sleep you get is as restorative as possible.
Of course, like any technology, some people will use it for negative purposes, which I believe would be to just "get by" on less sleep, rather than optimize your health through better sleep.
For the afficionados, there's an excellent paper titled "The neurobiological basis of narcolepsy" published in Nature Reviews Neuroscience which examines the relationship between orexin and sleep as it relates to narcolepsy patients: https://pmc.ncbi.nlm.nih.gov/articles/PMC6492289/
In narcolepsy type 1 (NT1), patients have severely diminished orexin levels. This appears to cause them to inappropriately enter REM sleep.
OP notes that the mutation lowering the sleep requirement causes an increase in orexin. I wonder whether the increased orexin could be inhibiting REM and perhaps facilitating a more restful architecture of sleep. Alternatively, perhaps elevated orexin levels during the day cause wakefulness such that you just don't need as much sleep, regardless of how efficient the sleep is.
It would be interesting to compare sleep tracking data of people with and without this mutation to see if there are significant differences in time spent in different sleep stages.
stared ·7 days ago
Sleep deprivation is one concern, but there’s a more subtle impact on cognitive functions (working memory, creativity, deep focus), overall health (particularly the endocrine and immune systems), and long-term health outcomes (such as an increased risk of dementia).
When I was younger, I was fascinated by various optimized sleep schedules. However, I noticed a stark contrast: many of my math friends consistently slept 9–10 hours a day. They needed that—not just to function in daily life but to achieve the deep focus required for their work. Living on less sleep might not affect immediate action (and in some cases, it might even seem to enhance focus on doing), but it can impair deeper, more complex thinking.
Some suggest that one of sleep's key roles is to help the brain regenerate. Chronic sleep deprivation, in turn, is linked to a higher risk of dementia. For anecdotal evidence: Churchill and Thatcher, known for boasting about sleeping only 4–5 hours a night, experienced significant cognitive decline later in life.
Show replies
exmadscientist ·7 days ago
This stuff? Orexin receptor antagonists? They work. Holy crap, do they ever work. Sleep quality better than the Z-drugs, great tolerability, no massive disruption going off them... when these things go off-patent they're going to be massive. Sleep quality was not perfect (maybe 80% of "normal"? I don't know) but that is absolutely minor compared to the alternative.
(And for the record, I'm off them now due to other stuff clearing up such that I don't need this level of sleep assistance anymore. Not because I can't afford them.)
I guess that's a long-winded way to say that if you're going to do questionably-advised sleep biohacking, orexin receptors are probably the place to start.
Show replies
londons_explore ·7 days ago
If you sleep 30% of the time, that's 30% of the time you aren't eating, mating, etc. Also, during sleep you are more vulnerable to predators. One would expect evolution to get rid of sleep in creatures who don't rely on sunlight cycles.
So, there must be some really good evolutionary reason for sleep.
Show replies
pedalpete ·7 days ago
Only focusing on the amount of time asleep is a significantly limited viewpoint, but I believe this will change in the coming years as we gather more knowledge of sleep and access to EEG data about our brain activity during sleep increases.
Only measuring sleep time is like measuring the health of a persons diet is by measuring how much time they spent eating, but of course, looking at macronutrients, calories, is the right way of doing it.
I'll be writing more about this in the coming months, but my current thinking is that the concept of "can we sleep less" isn't the correct approach, and can be dangerous. At AffectableSleep.com - we increase the efficiency of deep sleep, and much of the research (https://affectablesleep.com/research) focuses on enhancing deep sleep in sleep deprived individuals (I'll post more research soon). This doesn't mean we should be sleeping less. A lack of quality sleep is already an epidemic in society, and massively underreported because the focus of the sleep industry has been the amount of time asleep, not the restorative functions of sleep.
Our goal isn't to help you sleep less, and we will need to be very clear in our marketing, but rather to ensure the sleep you get is as restorative as possible.
Of course, like any technology, some people will use it for negative purposes, which I believe would be to just "get by" on less sleep, rather than optimize your health through better sleep.
You can find out more at https://affectablesleep.com
Show replies
nosefurhairdo ·7 days ago
In narcolepsy type 1 (NT1), patients have severely diminished orexin levels. This appears to cause them to inappropriately enter REM sleep.
OP notes that the mutation lowering the sleep requirement causes an increase in orexin. I wonder whether the increased orexin could be inhibiting REM and perhaps facilitating a more restful architecture of sleep. Alternatively, perhaps elevated orexin levels during the day cause wakefulness such that you just don't need as much sleep, regardless of how efficient the sleep is.
It would be interesting to compare sleep tracking data of people with and without this mutation to see if there are significant differences in time spent in different sleep stages.
Show replies